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Certain mobile genetic elements, eg, the transposon Tn10, contain two genes involved in resistance: a resistance gene, tetA, and a regulatory gene, tetR, which are transcribed from divergent promoters that are regulated by tetracycline? Please frailly go just read this, some times we just need to give a try of herbal Medicine to see for our self?

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Other gene mutations are also known to contribute to development of resistance.